Asociación entre anticoagulante lúpico positivo y niveles elevados de factor VIII como riesgo adicional de trombosis.

Martha Leonor Castillo Bohórquez; Yurany  Duarte; Gloria  Ramos; Elena Muñoz Zambrano

doi:10.22490/

Association between positive lupus anticoagulant and elevated levels of factor VIII as an additional risk of thrombosis

Asociación entre anticoagulante lúpico positivo y niveles elevados de factor VIII como riesgo adicional de trombosis.

Published 2025-08-21

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Vol. 24 No. 45 (2025): 2025-02

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Castillo Bohórquez, M. L., Duarte, Y., Ramos, G., & Muñoz Zambrano, . E. (2025). Association between positive lupus anticoagulant and elevated levels of factor VIII as an additional risk of thrombosis. Revista Nova, 24(45), 85-99. https://doi.org/10.22490/

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https://doi.org/10.22490/

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Martha Leonor Castillo Bohórquez

Universidad Colegio Mayor de Cundinamarca

https://orcid.org/0000-0001-6729-1357

Yurany Duarte

Universidad Colegio Mayor de Cundinamarca

https://orcid.org/0000-0002-4137-2244

Gloria Ramos

Universidad Nueva Granada

Elena Muñoz Zambrano

Universidad Nacional Mayor de San Marcos

https://orcid.org/0000-0002-2560-3903

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Antiphospholipid syndrome

lupus anticoagulant

thrombosis

factor VIII

Introduction. Lupus anticoagulant (LA), an autoantibody associated with thrombotic di sorders, interferes with coagulation tests. Elevated levels of factor VIII:C have been shown to constitute an independent thrombotic risk factor. Objective. To associate factor VIII activity in patients with positive lupus anticoagulant with an additional risk of thrombosis. Methodology. A descriptive cross-sectional study. 51 plasma samples with positive lupus anticoagulant were evaluated, with factor VIII:C and fibrinogen assays. Nonparametric statistical tests and the parallelism test were applied to confirm true deficiencies. Results. 42 samples had normal factor VIII:C concentrations, 5 showed mild deficiency of this fac

tor, and 4 showed elevated factor VIII:C levels. Of these, 2 also had elevated fibrinogen, and one had only elevated fibrinogen. The association between lupus anticoagulant and simultaneous elevation of Factor VIII:C and fibrinogen suggests significant thrombotic risk. Conclusions. The results demonstrate the importance of a comprehensive clinical evaluation of patients receiving lupus anticoagulant therapy, considering factor VIII:C as a marker of thrombotic risk. The parallelism test is recommended to assess factor elevations and actual risk.

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